• 文献标题:   Graphene quantum dots for the inhibition of beta amyloid aggregation
  • 文献类型:   Article
  • 作  者:   LIU YB, XU LP, DAI WH, DONG HF, WEN YQ, ZHANG XJ
  • 作者关键词:  
  • 出版物名称:   NANOSCALE
  • ISSN:   2040-3364 EI 2040-3372
  • 通讯作者地址:   Univ Sci Technol Beijing
  • 被引频次:   37
  • DOI:   10.1039/c5nr06282a
  • 出版年:   2015

▎ 摘  要

The aggregation of A beta peptides is a crucial factor leading to Alzheimer's disease (AD). Inhibiting the A beta peptide aggregation has become one of the most essential strategies to treat AD. In this work, efficient and low-cytotoxicity inhibitors, graphene quantum dots (GQDs) are reported for their application in inhibiting the aggregation of A beta peptides. Compared to other carbon materials, the low cytotoxicity and great biocompatibility of GQDs give an advantage to the clinical research for AD. In addition, the GQDs may cross the blood-brain barrier (BBB) because of the small size. It is believed that GQDs may be therapeutic agents against AD. This work provides a novel insight into the development of Alzheimer's drugs.