• 文献标题:   Novel Poly(e-caprolactone)/Graphene Scaffolds for Bone Cancer Treatment and Bone Regeneration
  • 文献类型:   Article
  • 作  者:   HOU YH, WANG WG, BARTOLO P
  • 作者关键词:   biomanufacturing, cancer, graphene, poly ecaprolactone, scaffold, tissue engineering
  • 出版物名称:   3D PRINTING ADDITIVE MANUFACTURING
  • ISSN:   2329-7662 EI 2329-7670
  • 通讯作者地址:   Univ Manchester
  • 被引频次:   0
  • DOI:   10.1089/3dp.2020.0051
  • 出版年:   2020

▎ 摘  要

Scaffold-based bone tissue engineering is the most relevant approach for critical-sized bone defects. It is based on the use of three-dimensional substrates to provide the appropriate biomechanical environment for bone regeneration. Despite some successful results previously reported, scaffolds were never designed for disease treatment applications. This article proposes a novel dual-functional scaffold for cancer applications, comprising both treatment and regeneration functions. These functions are achieved by combining a biocompatible and biodegradable polymer and graphene. Results indicate that high concentrations of graphene enhance the mechanical properties of the scaffolds, also increasing the inhibition on cancer cell viability and proliferation.