▎ 摘　　要

Graphene oxide-Fe3O4 (GO-Fe3O4) nanocomposite was synthesized by a facile chemical co-precipitation method. The GO-Fe3O4 was used as magnetic sorbent to extract the eight psychoactive drugs from urine samples. The analytes are morphine (MOR), 6-monoacetylmorphine (6-MAM), amphetamine (AMP), methamphetamine (MAMP), codeine, cocaine, dolantin and benzoylecgonine (BZE), which were determined by ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). This method has high selectivity for the target analytes. The limit of detection (LOD) and limit of quantification (LOQ) were 0.02-0.2 mu g L-1 and 0.05-0.5 mu g L-1, respectively. The Mandel's fitting test revealed good linearity within all linear ranges. The linear ranges were calculated as 0.05-1000 mu g L-1 for AMP, MAMP, cocaine and dolantin; 0.1-1000 mu g L-1 for 6-MAM and codein; and 0.5-1000 mu g L-1 for MOR and BZE. The recoveries ranged in 80.4-105.5%. The intra-day and inter-day RSDs are in the range of 2.7-13.1% and 3.9-13.7%, respectively. Magnetic solid phase extraction (MSPE) with GO-Fe3O4 provides a convenient, rapid and green sample pretreatment method for extracting the target psychoactive drugs from urine. This methodology can be used for simultaneous or individual detection of eight major psychoactive drugs with high sensitivity. This method has high potential in clinical and forensic areas for psychoactive drugs analysis.