▎ 摘　　要

The authors describe the fabrication of a stationary phase for use in enantioseparation in capillary electrochromatography (CEC). The stationary phase was obtained by covalent immobilization of graphene oxide (GO) on the inner walls of a fused-silica capillary. Methyl-beta-cyclodextrin was used as the chiral selector, and the enantiomers were detected by UV absorptiometry. Compared with uncoated fused-silica capillary, obviously improved separation of three tested drug enantiomers was obtained in the GO-polymer coated capillary column (the resolution of Naproxen: 0 -> 1.56, Warfarin: 0 -> 1.89 and Pranoprofen:0 -> 1.51). The effects of buffer pH, type and proportion of organic modifier, concentration of chiral selector and applied voltage were optimized. Molecular modeling was applied to demonstrate the mechanism of enantioseparation, which showed a good agreement with the experimental results.