▎ 摘　　要

Fusarium graminearum (F. graminearum), a pathogen for Fusarium head blight (FHB) on wheat, significantly reduces wheat yield and poses potential threats to human food safety. In this study, graphene oxide (GO) modified chitosan (GO-CS composite) was synthesized and its antifungal activity against F. graminearum in vitro and in vivo was evaluated. The (HNMR)-H-1 and FTIR results revealed the reaction between the carboxyl groups in GO and the amino groups in chitosan (CS). In vitro, the combination of GO and CS resulted in a significant synergistic inhibitory effect on the mycelial growth of F. graminearum relative to single GO or CS. The EC50 value of the GO-CS composite was 14.07 mu g/mL, which was much lower than that of GO or CS alone. In vivo, the GO-CS composite significantly reduced the disease incidence and severity compared with single GO or CS, and the control efficacy could reach 60.01 %. Microbial cells might be ultimately damaged when interacting with GO-CS due to various mechanisms such as biological effects and physical barriers. Overall, the combination of GO and CS provides new opportunities for their application in the control of fungi.