▎ 摘　　要

Breast cancer (BC) is the most occurring cancer in females and the second most commonly occurring cancer world-wide. Early detection of BC may ease the treatment and prevent the cancer from spreading beyond the breast. However, conventional screening tests lack the required sensitivity for early detection and have long detection times. Consequently, different BC biosensor strategies, which include optical, electrical, electrochemical, and mechanical biosensors, have been studied in recent years. Electrical biosensors, specifically, field effect transistors (FETs), are attractive for point-of-care applications with short detection time capabilities. Incorporation of nanomaterials in FETs can increase their sensitivity as a biosensor. Recently, graphene-based materials have been increasingly studied for BC FET biosensors because of graphene's outstanding electrical and mechanical properties. This review will present the latest strategies in graphene-based FETs for BC biosensing, and compare the different graphene-based transducers, biomarkers, bioreceptor materials, and device configurations. The limit of detection (LOD) of the state-of-art devices will be compared for different analytes and the mobility and "ON" and "OFF" current ratios would be analyzed for each device. Insight to the device's electrical properties effect over the performance of the device would be discussed. Lastly, prospects and current challenges, and potential strategies for signal amplification and performance enhancement would also be covered. (C) 2020 Elsevier Ltd. All rights reserved.