▎ 摘　　要

This work was designed to develop an electrochemical sensor based on molecular imprinted polyaniline membranes onto reduced graphene oxide (RGO) and gold nanoparticles (AuNPs) modified glassy carbon (GC) electrode for dapsone (DDS) determination. The prepared RGO/AuNPs/PANI-MIPs nanocomposite was characterized by Ultra-Violet-Visible (UV-Vis), Fourier transform infrared spectroscopy (FT-IR) and scanning electronic microscopy (SEM) images. The feature of the imprinted electrode was evaluated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and impedance spectroscopy (IS). Throughout this study several analytical parameters, such as incubation time, pH value, concentration of monomer/template molecules and electro-polymerization cycles were investigated. Under the optimized conditions, the experimental results showed best analytical performances for DDS detection with a sensitivity of 0.188 omega/mol L-1, a linear range from 1.0x10(-7) M to 1.0x10(-3) M and a detection limit of 6.8x10(-7) M. The bioanalytical sensor was applied to the determination of dapsone in real samples with high selectivity and recovery.