• 文献标题:   Microstructure, morphology and physicochemical properties of nanocomposites containing hydroxyapatite/vivianite/graphene oxide for biomedical applications
  • 文献类型:   Article
  • 作  者:   ELNAGGAR ME, ABU ALI OA, SALEH DI, ABUSAIED MA, AHMED MK, ABDELFATTAH E, MANSOUR SF
  • 作者关键词:   antibacterial, cell viability, corrosion, graphene oxide, hydroxyapatite, vivianite
  • 出版物名称:   LUMINESCENCE
  • ISSN:   1522-7235 EI 1522-7243
  • 通讯作者地址:  
  • 被引频次:   11
  • DOI:   10.1002/bio.4171 EA DEC 2021
  • 出版年:   2022

▎ 摘  要

Designing a nanocomposite that accumulates biocompatibility and antimicrobial behaviour is an essential requirement for biomedical applications. Hydroxyapatite (HAP), graphene oxide, and vivianite in one ternary nanocomposite with three phases and shapes led to an increase in cell viability to 97.6% +/- 4 for the osteoblast cells in vitro. The obtained nanocomposites were investigated for their structural features using X-ray diffraction, while the microstructure features were analyzed using a scanning electron microscope (SEM) and a transmission electron microscope. The analysis showed a decrease in the crystal size to 13 nm, while the HAP grains reached 30 nm. The elongated shape of vivianite reached 200 nm on SEM micrographs. The monoclinic and hexagonal crystal systems of HAP and vivianite were presented in the ternary nanocomposite. The maximum roughness peak height reached 236.1 nm for the ternary nanocomposite from 203.3 nm, while the maximum height of the roughness parameter reached 440.7 nm for the di-nanocomposite of HAP/graphene oxide from 419.7 nm. The corrosion current density reached 0.004 mu A/cm(2). The ferrous (Fe2+) and calcium (Ca2+) ions released were measured and confirmed. Therefore, the morphology of the nanocomposites affected bacterial activity. This was estimated as an inhibition zone and reached 14.5 +/- 0.9 and 13.4 +/- 1.1 mm for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) after 24 h. The increase in viability and the antibacterial activity refer to the compatibility of the nanocomposite in different medical applications.