▎ 摘　　要

Graphene/Room temperature ionic liquids (GN/IL) nanocomposite was prepared by grinding graphene and ionic liquid 1-buty1-3-methylimidazolium bromide (BMIMPF6) which mixed together in appropriate proportion. Atomic force microscopy (AFM) was utilized to characterize the formation of the GN-ILs. Due to the synergistic effect between ionic liquids and graphene, the nanocomposite exhibited excellent performance toward H2O2 reduction. A novel uric acid (UA) electrochemical sensor was fabricated based on uricase-GN/IL modified glassy carbon electrode. The experimental results showed that the response displayed a good linear response toward UA in the concentration range from 0. 002 4. 5 mmol/L. The correlation coefficient was 0. 995 and the detection limit was 0. 85 mu mol/L. The easily prepared electrochemical sensor had favorable stability and selectivity and could be applied to the quick determination of UA in human serum, thus providing a new UA detection method for clinical trial.