▎ 摘　　要

A simple, highly sensitive voltammetric method for the determination of urapidil at poly(sodium4-styrenesulfonate) functionalized graphene-modified electrode (PSS-Gr/GCE) was described. Based on the PSS-Gr composites-modified glassy carbon electrode as a simple voltammetric sensor, it exhibited good conductivity and high sensitivity to urapidil. Under the optimize condition, a good linear relationship was obtained between peak currents and urapidil concentrations in the wider range of 2.0 x 10(-9-)8.0 x 10(-8) mol L-1 and 2.0 x 10(-7)-2.0 x 10(-5) mol L-1 with detection limit of 8 x 10(-10) mol L-1 (S/N = 3). Based on the high sensitivity and good selectivity of the proposed electrode, the proposed method could apply to the detect of urapidil in urapidil sustained release tablets with satisfactory results.