▎ 摘　　要

In this work, a small diameter tubular vascular graft (inner diameter < 5 mm) was prepared from electrospun polyvinyl alcohol (PVA) containing graphene. Nanofibrous nanocomposite scaffolds showed high porosity with an average pore size of 5-6 nm and exhibited exfoliated morphology. Measurement of the water contact angle of the fibrous nanocomposite scaffold indicated a significant change in hydrophilicity on the addition of hydrophobic additives. To examine further in vitro biocompatibility, endothelial cells were seeded on the flat and tubular nanocomposite scaffolds and cultured over 4 days. The results indicated that the cells could adhere and proliferate well on nanocomposite scaffolds than neat PVA. The 3-(-4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide (MTT) assay exhibited no toxic effect of materials used in scaffolds while by loading graphene up to 3 wt% to PVA, cell proliferation enhanced considerably over 96 h. This approach, combining artery-like structure and efficient endothelization, might contribute to the clinical translation of tissue engineering vascular graft.