• 文献标题:   Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells
  • 文献类型:   Article
  • 作  者:   YOON HJ, SHANKER A, WANG Y, KOZMINSKY M, JIN Q, PALANISAMY N, BURNESS ML, AZIZI E, SIMEONE DM, WICHA MS, KIM JS, NAGRATH S
  • 作者关键词:  
  • 出版物名称:   ADVANCED MATERIALS
  • ISSN:   0935-9648 EI 1521-4095
  • 通讯作者地址:   Univ Michigan
  • 被引频次:   67
  • DOI:   10.1002/adma.201600658
  • 出版年:   2016

▎ 摘  要

A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.