• 文献标题:   Direct noncovalent conjugation of folic acid on reduced graphene oxide as anticancer drug carrier
  • 文献类型:   Article
  • 作  者:   PARK YH, PARK SY, IN I
  • 作者关键词:   reduced graphene oxide, noncovalent interaction, folic acid, targeted drug delivery, anticancer drug carrier
  • 出版物名称:   JOURNAL OF INDUSTRIAL ENGINEERING CHEMISTRY
  • ISSN:   1226-086X EI 1876-794X
  • 通讯作者地址:   Korea Natl Univ Transportat
  • 被引频次:   27
  • DOI:   10.1016/j.jiec.2015.05.021
  • 出版年:   2015

▎ 摘  要

Conjugate of reduced graphene oxide with folic acid (rGO/FA) was prepared through a completely noncovalent functionalization method. rGO/FA conjugate was soluble in physiological media with high dispersion stability and enabled the accumulation of hydrophobic doxorubicin (DOX) and CdSe quantum dot (QD) as an anticancer drug and a fluorescent tag, respectively. rGO/FA conjugate loaded with DOX showed specific targeting to MDA-MB 231 cells, excellent drug-release efficiency and cytotoxicity in vitro. Considering the simplicity and extendibility of noncovalent functionalization methods, rGO/FA conjugate can be widely utilized for the designing of new graphene-based nanocarriers. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.