▎ 摘　　要

In this paper, we selected biocompatible carboxylated graphene oxide (GeneO-COOH) as a base material. The nanohybrid drug carriers composed of GeneO-COOH and cyclodextrin (beta-CD), have been successfully synthesized through esterification and self-assembly technique. The nanohybrid drug carriers of GeneO-COO-beta-CD were characterized by X-ray diffraction (XRD), fourier infrared spectroscopy (FTIR), thermogravimetric analysis (TG), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and solubility experiments. Results indicated that the nanohybrid was obtained with GeneO-COOH forming the core and a large number of beta-CD molecules forming the shell with a special structure. In the nanohybrid, the westerification between GeneO-COOH and beta-CD led to the formation of covalent bonds, while adjacent beta-CD molecules engineer an outer shell composed of 100 beta-CD molecules (ca. 800 nm of thickness) in the form of a layer-by-layer self-assembly due to hydrogen-bonding interaction. The obtained novel nanohybrid drug carriers of GeneO-COO-beta-CD possessed good dispersibility in water media and the solutions were found to remain stable for 12 months, providing a possibility for further applications in biology, medicine, agriculture and other fields. (C) 2016 Published by Elsevier B.V.