▎ 摘　　要

A miniaturized graphene-based pipette tip extraction (M-G-PTE) method coupled with liquid chromatography-ultraviolet detection was developed for rapid screening of sulfadimidine, sulfachloropyridazine, sulfamonomethoxine, and sulfachloropyrazine residues in bovine milk. Because of the large surface area and unique chemical structure of graphene, an M-G-PTE device packed with 3.0 mg graphene could handle 2.0 mL of milk samples at one time. This M-G-PTE device showed better adsorption performance for sulfonamides (SAs) than those packed with other adsorbents such as C-18, HLB, SCX, PCX, and multiwalled carbon nanotubes. Under the optimized conditions, good linearity was obtained in the range of 0.05-6.0 mu g g(-1), with a correlation coefficient (r(2)) of >= 0.9991. The recoveries at three spiking levels ranged from 90.1% to 113.5% with relative standard deviations (RSDs) of