• 文献标题:   Fabrication and Characterization of Polyetherimide Electrospun Scaffolds Modified with Graphene Nano-Platelets and Hydroxyapatite Nano-Particles
  • 文献类型:   Article
  • 作  者:   KOSTOPOULOS V, KOTROTSOS A, FOURIKI K, KALARAKIS A, PORTAN D
  • 作者关键词:   solution electrospinning, scaffold, bone tissue engineering, polyetherimide, gnp, hydroxyapatite, sem, tem, contact angle, mechanical propertie
  • 出版物名称:   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  • ISSN:  
  • 通讯作者地址:   Univ Patras
  • 被引频次:   1
  • DOI:   10.3390/ijms21020583
  • 出版年:   2020

▎ 摘  要

Solution electrospinning process (SEP) is a versatile technique for generating non-woven fibrous materials intended to a wide range of applications. One of them is the production of fibrous and porous scaffolds aiming to mimic bone tissue, as artificial extracellular matrices (ECM). In the present work, pure and nano-modified electrospun polyetherimide (PEI) scaffolds have been successfully fabricated. The nano-modified ones include (a) graphene nano-platelets (GNPs), (b) hydroxyapatite (HAP), and (c) mixture of both. After fabrication, the morphological characteristics of these scaffolds were revealed by using scanning electron (SEM) and transmission electron (TEM) microscopies, while porosity and mean fiber diameter were also calculated. In parallel, contact angle experiments were conducted so that the hydrophilicity level of these materials to be determined. Finally, the mechanical performance of the fabricated scaffolds was investigated by conducting uniaxial tensile tests. Iota n future work, the fabricated scaffolds will be further utilized for investigation as potential candidate materials for cell culture with perspective in orthopedic applications.