• 文献标题:   Application of Graphene in Neural Activity Recording
  • 文献类型:   Review
  • 作  者:   LV SY, ZOU L, GUAN SL, LI HB
  • 作者关键词:   graphene, neural electrode, electrophysiology, interface, stable chronic recording
  • 出版物名称:   PROGRESS IN CHEMISTRY
  • ISSN:   1005-281X
  • 通讯作者地址:  
  • 被引频次:   1
  • DOI:   10.7536/PC200811
  • 出版年:   2021

▎ 摘  要

As a powerful tool for monitoring brain activities, neural electrodes have been playing a crucial role in the understanding of brain functions and the treatment of neurological disorders. In particular, the construction of a stable electrode-neural interface is critical for the stable chronic neural recording. However, conventional neural electrodes are mainly constructed with rigid materials, whose Young's moduli are several orders of magnitude higher than that of the brain tissue. This large mechanical mismatch causes the micromotion of the neural electrodes, which elicits inflammatory response of the brain tissue and thus limits the stable chronic neural recording. With the one-atom thickness, graphene has been considered as a promising active material for neural electrodes with stable electrode-neural interfaces for its high conductivity, excellent flexibility and good biocompatibility. In this review, we provide an overview of graphene for neural activity recording, from their modulation on the growth of neurons to applications in both in vitro and in vivo neural activity recording. At last, challenges and prospects of graphene for neural activity recording are proposed.