▎ 摘　　要

Cancer growth is a developing significant public health threat, and notwithstanding the advances in biomedical research and innovation, a pressing need is felt for the progress of new anticancer drugs. Sulfated polysaccharides, such as ulvan from green macroalgae, exhibit a diverse range of biological applications. In this study, a novel D-mannose-mediated targeted drug delivery system (GO-CH-Ma) for targeting glioblastoma cancer was developed by loading Ulvan lactua as the anticancer model drug onto functionalized graphene oxide. Ultraviolet spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and Zeta potential were used to describe the main physicochemical properties of the chitosan-functionalized graphene oxide (GO-CH). Similarly, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) enabled the study of surface morphology. The entrapment of ulvan on GO-CH-Ma has been observed to be 88%. The biocompatibility of the nanocarrier and drug-loaded nanocarrier was studied via hemolysis and anti-inflammatory assay. The in vitro drug release profile of ulvan revealed a pH-dependent-controlled release system observed by UV-Visible analysis. Moreover, a human glioblastoma cell line (U87) was used to examine the preliminary in vitro cytotoxicity. Finally, a mannose-decorated GO-CH carrier loaded with ulvan demonstrated a promising targeted drug delivery system to treat in vitro glioblastoma.