• 文献标题:   Synthesis of biologically-active reduced graphene oxide by using fucoidan as a multifunctional agent for combination cancer therapy
  • 文献类型:   Article
  • 作  者:   KANG S, HONG YL, KU BC, LEE S, RYU S, MIN DH, JANG H, KIM YK
  • 作者关键词:   fucoidan, graphene oxide, reduction, surface functionalization, cancer therapy
  • 出版物名称:   NANOTECHNOLOGY
  • ISSN:   0957-4484 EI 1361-6528
  • 通讯作者地址:   Korea Inst Sci Technol
  • 被引频次:   1
  • DOI:   10.1088/1361-6528/aadfa5
  • 出版年:   2018

▎ 摘  要

A therapeutic reduced graphene oxide (RGO) is synthesized by using fucoidan (Fu) as the reducing and surface functionalizing agent. The synthesized Fu-RGO exhibits promising characteristics for therapeutic applications such as high dispersity in aqueous media, biocompatibility, selective cytotoxicity to cancer cells, high loading capacity of the anticancer drug, and photothermal conversion effect. Therefore, Fu-GO is successfully harnessed as a combinatorial cancer treatment platform through bio-functional (Fu), chemo (doxorubicin (Dox)) and photothermal (RGO with near-infrared irradiation) modalities.