▎ 摘　　要

A novel electrochemical method was designed and developed for measurement of Alfuzosin based on combination of a new sensor with Coulometric FFT Linear sweep Voltammetry. The electrode was constructed by the pareparation of a matrix of ZrO2 in graphene oxide and ionic liquid (1-butyl-3-methylimidazolium tetra fluoroborate) on glassy carbon electrode. The experimental conditions, such as pH, amount of nanoparticles and potential scan rate were optimized for the electrochemical measurement. The linearly concentrations ranges of Alfuzosin was from 2.0 -150 nM with a detection limit of 0.5x10(-9) M. Moreover, the proposed sensor exhibits a good reproducibility and accuracy, the response time less than 10 s, high sensitivity with repeatability (R.S.D value of 2.6%) and long term stability (45 days).