• 文献标题:   Photodynamic antimicrobial activity of benzimidazole substituted phthalocyanine when conjugated to Nitrogen Doped Graphene Quantum Dots against Staphylococcus aureus
  • 文献类型:   Article
  • 作  者:   SEN P, NWAHARA N, NYOKONG T
  • 作者关键词:   zinc phthalocyanine, benzimidazole, photodynamic antimicrobial therapy, staphylococcus aureu, photophysicochemical propertie
  • 出版物名称:   MAIN GROUP CHEMISTRY
  • ISSN:   1024-1221 EI 1745-1167
  • 通讯作者地址:  
  • 被引频次:   9
  • DOI:   10.3233/MGC-210030
  • 出版年:   2021

▎ 摘  要

In this study, peripherally benzimidazole unit substituted ZnPc (1) and its conjugation to nitrogen doped graphene quantum dot (NGQD) as potential phthalocyanine support via pi-pi stacking have been presented and fully characterized. The bottom-up solution-based synthesized NGQDs was conjugated non-covalently to zinc phthalocyanine to form NGQDs-Pc nanoconjugates. The photophysical and photochemical properties of both such as absorption, fluorescence, fluorescence life time, singlet oxygen quantum yields, triplet state quantum yields and exited state lifetimes were investigated in solutions. We observed a decrease in the fluorescence quantum yields with a corresponding increase in the triplet quantum yield and singlet oxygen quantum yield of the nanoconjugates in comparison to the phthalocyanine complex alone. Photodynamic antimicrobial chemotherapy activities (PACT) of ZnPc alone and its nanoconjugate were determined towards Staphylococcus aureus.