▎ 摘　　要

The integration of metal, metal oxides or metal alloy nanostructures with graphene increases the surface area, active sites for binding analytes, conductivity as well as mechanical strength of the biosensor. Graphene-metallic nanocomposites by their synergistic effect exhibit greater sensitivity for the detection of a variety of biomolecules. Herein, this review addresses the most recent progress on the design and fabrication of graphene metallic nano-biointerfaces in electrochemical biosensing, detection of biomolecules ranging from most common analytes to sophisticated molecules with greater sensitivity as well as good selectivity from the real-time sample in presence of common interfering substances. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.