▎ 摘　　要

In this work, a novel electrochemical sensor based on graphene nanoplatelets (GNPs) film was designed and prepared to detect rifampicin. GNPs were dispersed in deionized-distilled water, and the suspension was modified onto the surface of glassy carbon electrode (GCE) by a drop-coating process. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to investigate the electrochemical behaviors of rifampicin on modified electrode with GNPs (GNPs/GCE). Several factors affecting the current response of rifampicin, including the types and concentration of support electrolyte solutions, the volume of GNPs solutions were investigated. Under the optimized conditions, the proposed GNPs/GCE showed a good response and recognition effect for rifampicin in sulfuric acid electrolytes. In the range of 10-3 mu M to 100 mu M, the modified electrode could achieve a good linear effect with a good coefficient of determination (R-2 = 0.996), and the limit of detection reached 0.5 nM. It could be used as a simple, fast and sensitive electrochemical sensor system for the detection and quantification of rifampicin.