• 文献标题:   Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells
  • 文献类型:   Article
  • 作  者:   NAYAK TR, ANDERSEN H, MAKAM VS, KHAW C, BAE S, XU XF, EE PLR, AHN JH, HONG BH, PASTORIN G, OZYILMAZ B
  • 作者关键词:   graphene, mesenchymal stem cell, cell differentiation, bone, osteogenesi
  • 出版物名称:   ACS NANO
  • ISSN:   1936-0851 EI 1936-086X
  • 通讯作者地址:   Natl Univ Singapore
  • 被引频次:   524
  • DOI:   10.1021/nn200500h
  • 出版年:   2011

▎ 摘  要

Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation Into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful Is to direct stem cells' proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate Is comparable to the one achieved with common growth factors, demonstrating graphene's potential for stem cell research.