▎ 摘　　要

Due to ultra-high reactivity, direct determination of free radicals, especially hydroxyl radical (center dot OH) with ultra-short lifetime, by field-effect transistor (FET) sensors remains a challenge, which hampers evaluating the role that free radical plays in physiological and pathological processes. Here, we develop a center dot OH FET sensor with a graphene channel functionalized by metal ion indicators. At the electrolyte/graphene interface, highly reactive center dot OH cuts the cysteamine to release the metal ions, resulting in surface charge de-doping and a current response. By this inner-cutting strategy, the center dot OH is selectively detected with a concentration down to 10(-9) M. Quantitative metal ion doping enables modulation of the device sensitivity and a quasi-quantitative detection of center dot OH generated in aqueous solution or from living cells. Owing to its high sensitivity, selectivity, real-time label-free response, capability for quasi-quantitative detection and user-friendly portable feature, it is valuable in biological research, human health, environmental monitoring, etc.