▎ 摘　　要

In this article, we constructed mesoporous silica-based nanoscale platform rGO/MSN/C18PEG for phototheraml-chemotherapy, in which the mesoporous silica grew on the reduced graphene oxide (rGO) via supramolecular interaction and octadecanoic acid modified PEG (C18PEG) was introduced to improve the solubility and stability. Further, the therapeutic drug doxorubicin (DOX) was loaded into this nanoplatform through noncovalent interaction to construct rGO/MSN/C18PEG@DOX delivery system. All obtained date indicated that rGO/MSN/C18PEG@DOX exhibited uniform nanoscale size and excellent stability. Compared with single chemotherapy or photothermal therapy, rGO/MSN/C18PEG@DOX showed enhanced anticancer efficacy due to combination of photothermal-chemotherapy, outlining the potential application for cancer theranostics.