▎ 摘　　要

In this study, a new molecularly imprinted polymer (MIP) based nanocomposite was synthesized then used to determine epinephrine (EPN) by the use of an electrochemical sensor modified by it. Typical techniques for the synthesis of MIP have disadvantages, such as weak binding sites, low mass transfer and low selectivity. One of the ways to improve electrochemical properties is the use of graphene oxide (GR-Ox) and modification of its surface. For this purpose, GR-Ox was initially magnetized (MGR-Ox), then its surface was coated with a silica layer, and gold nanoparticles (AuNPs) were coated on its surface. Subsequently, copolymerization of methacrylic acid (MAA) and N,N'-methylene-bis-acrylamide (MBA) in the presence of EPN was performed on the MGO-AuNPs surface. Afterwards, a selective carbon paste electrode (CPE) with synthetic nanocomposite was fabricated to detect EPN. Under optimal conditions, a linear range from 10(-8) to 5.0 x 1.0(-7) M was obtained for the measurement of EPN in urine and blood with a detection limit of 5 x 10(-9) M (S/N = 3).