▎ 摘　　要

In this work, graphene oxide/metal-organic framework-74/Fe3O4/polytyramine (GO/MOF-74/Fe3O4/PTy) nanoporous composite was synthesized as a sustainable sorbent for magnetic dispersive micro-solid phase extraction (MD-mu-SPE) of prokinetic drugs. The new nanosacle sorbent in combination with high performance liquid chromatography-ultraviolent detection (HPLC-UV) was applied for simultaneous trace quantification of target drugs in human plasma. MOF-74 and PTy were used as surface modifiers to improve the properties of GO nanosheets, such as surface area-to-volume ratio, adsorption capacity, hydrophobic interactions and selectivity. A composite of GO/MOF-74/Fe3O4 was fabricated and then an oxidative polymerization of tyramine was performed on the surface of sorbent using horseradish peroxidaze (HRP) enzyme as a catalyst. The characterization of the hybrid sorbent was evaluated using scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and Fourier transform-infrared (FT-IR) spectroscopy. The limit of detections (LODs, S/N = 3) for domperidone (DOM) and itopride (ITP) were 0.4 and 1.1 ng mL(-1), respectively. Notable linearity (0.995 >= r(2) >= 0.991) and practical dynamic concentration ranges of 1.5-1100.0 ng mL(-1) and 4.0-1750.0 ng mL(-1) were obtained for DOM and ITP, respectively. Intra-assay (