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  • 文献标题:   Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system
  • 文献类型:   Article
  • 作　　者:   ZHOU L, ZHOU L, WEI SH, GE XF, ZHOU JH, JIANG HJ, LI FY, SHEN J
  • 作者关键词:   hypocrellin a, 7ethyl10hydroxycamptothecin, graphene oxide, combination therapy
  • 出版物名称:   JOURNAL OF PHOTOCHEMISTRY PHOTOBIOLOGY BBIOLOGY
  • ISSN:   1011-1344
  • 通讯作者地址:   Nanjing Normal Univ
  • 被引频次:   50
  • DOI:   10.1016/j.jphotobiol.2014.04.010
  • 出版年:   2014

▎ 摘　　要

Previous research indicated that graphene oxide (GO) can be used to deliver photosensitive anticancer drug, Hypocrellin A (HA), in photodynamic therapy (PDT). However, the anticancer activity of HA was obviously decreased after been loaded on GO. To solve this problem, a chemotherapy drug, 7-ethyl-10-hydroxycamptothecin (SN-38), was co-loaded on the HA loaded GO (HA/SN-38/GO) as a multimodal carrier for the synergistic combination of PDT and chemotherapy for cancer. In vitro results showed that the combination therapy exhibited a synergistic antiproliferative effect compared with PDT and chemotherapy alone. Therefore, HA/SN-38/GO delivery system has the potential to offer dual therapies for the synergistic combination of PDT and chemotherapy for the treatment of cancer. (C) 2014 Elsevier B.V. All rights reserved.