▎ 摘　　要

Rapid growth of nanotcchnology has accelerated immense possibility of engineered nanomaterials (ENMs) exposure by human and living organisms. In this context, wide range applications of graphene based nanomatcrials (GBNMs) may inevitably cause their release into the environment. Consequently, potential risks to the ecological system and human health is consistently increasing due to the probable ingestion of GBNMs by mean of contaminated water or food sources. Further, gut microbiome is known to play a profound impact on the health status of human being and has been recognized as the most exciting advancement in the biomedical science. Recent studies has shown vital role of ENMs to alter gut microbiome and thereby changed pathological status of organisms. Therefore, in this review results of numerous studies dedicated to explore the impact of GBNMs on gut microbiome and thereby various pathological status have been summarized. Dietary exposure of different types of GBNMs [e.g. graphene, graphene oxide (GO), partially reduced graphene oxide (PRGO), graphene quantum dots (GQDs)] have been evaluated on the gut microbiome through numerous in vitro and in vivo models. Moreover, emphasis has been made to evaluate different physiological responses with the short/long-term exposure of GBNMs, particularly in gastrointestinal tract (GET) and its correlation with gut microbiome and the health status. It is reviewed that exposure of GBNMs can exert significant impact which alter the composition, diversity and function of gut microbiome. This may further appear in terms of enteric disorder along with numerous pathological changes e.g. IEC (intestinal epithelial cells) colitis, lysosomal dysfunction, inflammation, shortened colon, resorbed embryo, retardation in skeletal development, low weight of fetus, early or late dead of fetus and IBD (inflammatory bowel disease) like symptoms. Finally, potential health risks due to the exposure of GBNMs have been discussed with future perspective.