• 文献标题:   Sulfonated Graphene-Oxide as Metal-Free Efficient Carbocatalyst for the Synthesis of 3-Methyl-4-(hetero)arylmethylene isoxazole-5(4H)-ones and Substituted Pyrazole
  • 文献类型:   Article
  • 作  者:   BASAK P, DEY S, GHOSH P
  • 作者关键词:   aldehyde, carbocatalyst, ethyl acetoacetate, isoxazole, pyranopyrazole, sulfonated graphene oxide
  • 出版物名称:   CHEMISTRYSELECT
  • ISSN:   2365-6549
  • 通讯作者地址:   Univ North Bengal
  • 被引频次:   8
  • DOI:   10.1002/slct.201904164
  • 出版年:   2020

▎ 摘  要

A straightforward, simple and unprecedented transformative protocol has been accomplished towards furnishing a wide variety of pharmaceutically promising functionalised 3-methyl-4-(hetero)arylmethylene isoxazole-5(4H)-ones and 6-Amino-3-methyl-4-phenyl-1,4-[2,3-c]pyrazole-5-carbonitriles. Sulfonated graphene oxide (SGO), a new class of heterogeneous carbocatalyst, was found to be efficient for thisone pot rapid conversion of isoxazoles and pyranopyrazoles from aldehyde. The prepared SGO was characterised by FEG-SEM, HR-TEM, FTIR and was recyclable up to 5(th) run without a significant drop in its catalytic activity. Metal free synthesis, good to excellent yield, high atom economy, usage of readily available starting material, operational simplicity, easy workup, and recyclable catalyst are the fundamental features of this protocol.