• 文献标题:   Lactobionic acid and carboxymethyl chitosan functionalized graphene oxide nanocomposites as targeted anticancer drug delivery systems
  • 文献类型:   Article
  • 作  者:   PAN QX, LV Y, WILLIAMS GR, TAO L, YANG HH, LI HY, ZHU LM
  • 作者关键词:   graphene oxide, lactobionic acid, doxorubicin, asgprs receptor, ph sensitive, targeted delivery
  • 出版物名称:   CARBOHYDRATE POLYMERS
  • ISSN:   0144-8617 EI 1879-1344
  • 通讯作者地址:   Donghua Univ
  • 被引频次:   40
  • DOI:   10.1016/j.carbpol.2016.06.024
  • 出版年:   2016

▎ 摘  要

In this work, we report a targeted drug delivery system built by functionalizing graphene oxide (GO) with carboxymethyl chitosan (CMC), fluorescein isothiocyanate and lactobionic acid (LA). Analogous systems without LA were prepared as controls. Doxorubicin (DOX) was loaded onto the composites through adsorption. The release behavior from both the LA-functionalized and the LA-free material is markedly pH sensitive. The modified GOs have high biocompatibility with the liver cancer cell line SMMC-7721, but can induce cell death after 24 h incubation if loaded with DOX. Tests with shorter (2 h) incubation times were undertaken to investigate the selectivity of the GO composites: under these conditions, neither DOX-loaded system was found to be toxic to the non-cancerous L929 cell line, but the LA-containing composite showed the ability to selectively induce cell death in cancerous (SMMC-7721) cells while the LA-free analogue was inactive here also. These findings show that the modified GO materials are strong potential candidates for targeted anticancer drug delivery systems. (C) 2016 Elsevier Ltd. All rights reserved.