• 文献标题:   Graphene-Based Nanomaterials: Potential Tools for Neurorepair
  • 文献类型:   Review
  • 作  者:   WANG Q, LI YH, JIANG WJ, ZHAO JG, XIAO BG, ZHANG GX, MA CG
  • 作者关键词:   graphene, neural cell, biocompatibility, biological activity, neurodegeneration, drug carrier
  • 出版物名称:   CURRENT PHARMACEUTICAL DESIGN
  • ISSN:   1381-6128 EI 1873-4286
  • 通讯作者地址:   Shanxi Univ Chinese Med
  • 被引频次:   0
  • DOI:   10.2174/1381612823666170828130526
  • 出版年:   2018

▎ 摘  要

Graphene, with its outstanding electrical properties, large surface area, and excellent mechanical properties, is found in a wide variety of applications in biomimetic substrates and biomedicine, with the result that there is growing interest in the effect of graphene-based nanomaterials on neural cells. This review sums up current research on the effectiveness of graphene and its derivatives on neural cells. We emphasize the biocompatibility of graphene and its derivatives, and how they affect the behavior of neural cells, including adhesion, proliferation, neurite outgrowth and differentiation. In addition, we discuss at great length the literature on graphene-based nanomaterials for drug delivery applications. While their in vivo effects on the nervous system remain to be explored, encouraging findings indicate that graphene-based nanomaterials have significant potential as novel therapies for neurodegenerative disease.