• 文献标题:   Blood Compatible Graphene/Heparin Conjugate through Noncovalent Chemistry
  • 文献类型:   Article
  • 作  者:   LEE DY, KHATUN Z, LEE JH, LEE YK, IN I
  • 作者关键词:  
  • 出版物名称:   BIOMACROMOLECULES
  • ISSN:   1525-7797 EI 1526-4602
  • 通讯作者地址:   Chungju Natl Univ
  • 被引频次:   139
  • DOI:   10.1021/bm101031a
  • 出版年:   2011

▎ 摘  要

Blood compatible graphene/heparin conjugate is simply formulated through noncovalent interaction between chemically reduced graphene and heparin. Charge repulsion of negatively charged heparin on graphene plates renders hydrophobic graphene to be solublized in aqueous media without any precipitation or aggregation even after 6 months. Unfractioned heparin (UFH) with higher molecular weight was effective for graphene solubilization while low molecular weight heparin (LMWH) was not. Noncovalently interacting heparin chains on graphene plates preserve their anticoagulant activity after conjugation with graphene. Graphene/UFH conjugate shows much enhanced anti factor Xa (FXa) activity of 29.6 IU/mL compared with pristine graphene oxide (GO; 1.03 IU/mL).