▎ 摘　　要

A glass carbon electrode modified with functionalized graphene has been fabricated due to its elusive two-dimentional structure and unique electronic properties. Electrochemical experiments indicated the modified electrode showed a preferable electrocatalytic activity for the oxidation of promethazine. Under the optimum conditions, the increase of response current is proportional to the promethazine concentration in the range of 2.0 x 10(-6) and 1.0 x 10(-3) M, with the detection limit of 4.2 x 10(-7) M. In addition, the developed sensor shows acceptable stability and reproducibility. These results demonstrate the viability of the use of graphene modified electrode as a potential amperometric sensor for pharmaceutical and clinical measurements.