• 文献标题:   Transfer-Printing of Single DNA Molecule Arrays on Graphene for High-Resolution Electron Imaging and Analysis
  • 文献类型:   Article
  • 作  者:   CERF A, ALAVA T, BARTON RA, CRAIGHEAD HG
  • 作者关键词:   graphene, dna, transmission electron microscopy, electron energy loss spectroscopy, nanopatterning, genetics/epigenetic
  • 出版物名称:   NANO LETTERS
  • ISSN:   1530-6984 EI 1530-6992
  • 通讯作者地址:   Cornell Univ
  • 被引频次:   28
  • DOI:   10.1021/nl202219w
  • 出版年:   2011

▎ 摘  要

Graphene represents the ultimate substrate for high-resolution transmission electron microscopy, but the deposition of biological samples on this highly hydrophobic material has until now been a challenge. We present a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis. This method is a necessary step toward the observation of single elongated DNA molecules with single base spatial resolution to directly read genetic and epigenetic information.