▎ 摘　　要

The present article demonstrates the synthesis of the nanocomposite of reduced graphene oxide (rGO) with CdSe and CdSe/V(2)O(5)core/shell quantum dots by a two-step facile synthesis approach and subsequently studies their relative biocompatibility in different cells. Various characterization techniques have been applied including transmission electron microscopy (TEM), an x-ray diffractometer (XRD) and Raman spectroscopy to confirm the successful formation of CdSe-rGO and CdSe/V2O5-rGO nanocomposites. The average sizes of CdSe and CdSe/V(2)O(5)QDs have found to be similar to 3 and 5.5 nm, respectively with a good dispersion over the surface of rGO nanosheets. A crystal phase change has occurred during the formation of the V(2)O(5)shell over the surface of CdSe QDs and confirmed through XRD. Raman spectroscopy has shown some useful insight of the surface state of CdSe and consequent changes in the surface with V(2)O(5)shell growth. Further, MTT and cell growth assays have been performed to analyze their biocompatibility in A549 and Hela cells with various concentrations of as-synthesized materials. Our results demonstrate the toxicity of CdSe-rGO nanocomposite to be substantially reduced by the growth of the V(2)O(5)shell. Thein vivostudies in Drosophila show a remarkable decrease in the reactive oxygen species (ROS) and apoptosis levels for a CdSe/V2O5-rGO composite as compared to a CdSe-rGO nanocomposite, which paves a promising pathway for the CdSe/V2O5-rGO nanocomposite to be used as an efficient biocompatible material.