• 文献标题:   Graphene foam as a biocompatible scaffold for culturing human neurons
  • 文献类型:   Article
  • 作  者:   D ABACO GM, MATTEI C, NASR BK, HUDSON EJ, ALSHAWAF AJ, CHANA G, EVERALL IP, NAYAGAM B, DOTTORI M, SKAFIDAS E
  • 作者关键词:   graphene foam, biocompatibility, human stem cell, human cortical neuron
  • 出版物名称:   ROYAL SOCIETY OPEN SCIENCE
  • ISSN:   2054-5703
  • 通讯作者地址:   Univ Melbourne
  • 被引频次:   2
  • DOI:   10.1098/rsos.171364
  • 出版年:   2018

▎ 摘  要

In this study, we explore the use of electrically active graphene foam as a scaffold for the culture of human-derived neurons. Human embryonic stein cell (hESC)-derived cortical neurons fated as either glutamatergic or GABAergic neuronal phenotypes were cultured on graphene foam. We show that graphene foam is biocompatible for the culture of human neurons, capable of supporting cell viability and differentiation of hESC-derived cortical neurons. Based on the findings, we propose that graphene foam represents a suitable scaffold for engineering neuronal tissue and warrants further investigation as a model for understanding neuronal maturation, function and circuit formation.