• 文献标题:   Mitigating the Cytotoxicity of Graphene Quantum Dots and Enhancing Their Applications in Bioimaging and Drug Delivery
  • 文献类型:   Article
  • 作  者:   CHANDRA A, DESHPANDE S, SHINDE DB, PILLAI VK, SINGH N
  • 作者关键词:  
  • 出版物名称:   ACS MACRO LETTERS
  • ISSN:   2161-1653
  • 通讯作者地址:   Indian Inst Technol Delhi
  • 被引频次:   37
  • DOI:   10.1021/mz500479k
  • 出版年:   2014

▎ 摘  要

Despite the promising photophysical properties of fluorescent graphene quantum dots (GQDs), their cellular toxicity needs to be addressed before their full potential could be completely realized in biomedicine. A simple method for mitigating the toxicity of GQDs by embedding them in PEG matrix is reported here. The enhanced biocompatibility of polymer modified, P-GQDs, is attributed to reduced reactive oxygen species generation, as measured by an intracellular ROS assay. We also demonstrate the enhanced loading and efficient intracellular delivery of therapeutics by P-GQDs.