• 文献标题:   (4-Ferrocenylethyne) phenylamine on Graphene as the Signal Amplificator to Determinate Dopamine and Acetaminophen Simultaneously
  • 文献类型:   Article
  • 作  者:   WANG LP, LIU ML, MENG Y, LI HT, ZHANG YY, YAO SZ
  • 作者关键词:   simultaneous electrochemical detection, 4ferrocenylethyne phenylamine, pipi stacking
  • 出版物名称:   CHINESE JOURNAL OF CHEMISTRY
  • ISSN:   1001-604X EI 1614-7065
  • 通讯作者地址:   Hunan Normal Univ
  • 被引频次:   12
  • DOI:   10.1002/cjoc.201201229
  • 出版年:   2013

▎ 摘  要

A novel (4-ferrocenylethyne) phenylamine functionalized graphene sheets (FEPA-GR), coupling with chitosan (CS) were used as a signal amplification platform for simultaneous and sensitive determination of dopamine (DA) and acetaminophen (AC). In this work, FEPA used as electron transfer mediator can be immobilized on GR surface via strong pi-pi stacking interaction between the conjugate chain of FEPA and GR, which effectively prevents FEPA electron mediator leaking from the electrode surface and amplified the signal. Transmission electron microscopy, FT-IR spectroscopy, UV-vis spectroscopy and electrochemical experiments results are all demonstrated the strong pi-pi stacking interaction between FEPA and GR. The resulted biosensor exhibited a fast response, remarkable electrocatalytic activity, perfect anti-interference ability and good stability for simultaneous detection of DA and AC. Under the optimum conditions, the oxidation peak currents of DA and AC were linearly correlated to their concentrations in the range of 2.0-135.0 mu mol.L-1 and 0.3-80.0 mu mol.L-1, respectively. The lower detection limits for DA and AC were 0.30 and 0.05 mu mol.L-1, respectively. The feasibility of the proposed method was validated by successfully applied to the simultaneous determination of DA and AC in serum samples with the standard addition method.