• 文献标题:   Studying the Sensitivity of Graphene for Biosensor Applications
  • 文献类型:   Article
  • 作  者:   USIKOV AS, LEBEDEV SP, ROENKOV AD, BARASH IS, NOVIKOV SV, PUZYK MV, ZUBOV AV, MAKAROV YN, LEBEDEV AA
  • 作者关键词:   graphene, silicon carbide, biosensor, fluorescein
  • 出版物名称:   TECHNICAL PHYSICS LETTERS
  • ISSN:   1063-7850 EI 1090-6533
  • 通讯作者地址:   Nitride Crystals Inc
  • 被引频次:   0
  • DOI:   10.1134/S1063785020050296
  • 出版年:   2020

▎ 摘  要

We have studied the response of graphene-film-based chips on SiC substrates (the relative change in the chip resistance) to coming into contact with fluorescein (C20H12O5) in a wide range of its concentrations in a phosphate-buffered saline solution: from 1 x 10(-3)to 1 x 10(4)ng/mL (seven orders of magnitude). Fluorescein detection seems to be a simple and cheap model experiment to study the sensory ability of graphene in the way of biochips manufacturing. It has been shown that chips with wide terraces on a surface with a step width of about 1000 nm and heights of up to 5 nm made it possible to construct the calibration dependences of chip response on fluorescein concentration.