▎ 摘　　要

A novel composite of poly (sodium-p-styrenesulfonate) functionalized graphene nanosheets (PSS-GNS) was prepared through reducing graphene oxide (GO) with hydrazine hydrate as the reducing agent and poly (sodium-p-styrenesulfonate) (PSS) as the protective agent. Then, the properties of PSS-GNS were characterized using ultraviolet-visible spectrometer (UV-Vis), Fourier transform infrared spectrometer (FTIR), X-ray diffraction (XRD), Raman spectrometer, scanning electron microscope (SEM), transmission electron microscope (TEM) and atomic force microscope (AFM). The results reveal that PSS-GNS synthesized are in the form of water-soluble and randomly dispersible nanosheets. Furthermore, the absorption behavior of PSS-GNS for rhodamine 6G used as a model anticancer drug was investigated, which demonstrate that PSS-GNS have a high loading capacity of 2. 77 mg/mg. Release profiles in vitro indicate that the release of R6G from PSS-GNS/R6G complexes is pH-dependent and slow-release. PSS-GNS also exhibits low cytotoxicity against cancer cells. PSS-GNS/R6G complexes were easily delivered into the cancer cells and sustained the slow release of R6G for a long time. In conclusion, PSS-GNS could be apromising carrier for anti-cancer drug delivery.