▎ 摘　　要

Polyelectrolyte complex (PEC) hydrogels composed of sodium carboxymethyl cellulose and chitosan reinforced with halloysite nanotubes (HNTs) and graphene oxide (GO) were prepared by polyelectrolyte complexation under acidic environment. Herein, we investigated the effect of HNTs (1.0-10.0 wt%) or HNTs (10.0 wt %)/GO (0.5-1.5 wt%) on the structure-property relationship in microstructural, rheological, mechanical, and cytotoxicity analysis for PEC hydrogels. The results showed highly porous microstructure (varying from 94.3% to 92.8%), stable physical-network and thermal stability of PEC hydrogels and significantly enhanced storage modulus and compressive mechanical properties (in wet state and dry state) of PEC hydrogels reinforced with HNTs/GO. The relative swelling ratio (%) and in vitro degradation of the PEC hydrogels were observed to decrease after the incorporation of HNTs or HNTs/GO content. In addition, PEC hydrogels supported human skin fibroblast cell attachment and proliferation and enhanced effect was observed when HNTs or HNTs/GO were added.