▎ 摘　　要

In this study, we present a new biosensor based on surface plasmon resonance (SPR) for the detection of two commonly used buffers: Dulbecco Phosphate Buffered Saline (PBS) and TRIS-Borate-EDTA Buffer (TBE). The proposed SPR sensor utilizes a combination of SrTiO3 (STO) and two-dimensional (2D) materials. In the angle interrogation method, using STO can almost double the sensitivity compared to using traditional SPR biosensors. Moreover, using a single sheet of graphene (SSG) can further improve the sensitivity. For PBS and TBE buffers, the highest sensitivities reached are 327.023 and 320.581 degrees/RIU with the structures SSG/35 nm Ag/ 14 nm STO and SSG/50 nm Ag/12 nm STO, respectively. We also investigate a set of 2D nanomaterials and found that the maximum sensitivity can be attained with WSe2 due to its lower real part of the refractive index. The results reveal that the proposed SPR biosensor is an efficient tool for biomedical applications.