• 文献标题:   Uniform Ultrasmall Graphene Oxide Nanosheets with Low Cytotoxicity and High Cellular Uptake
  • 文献类型:   Article
  • 作  者:   ZHANG H, PENG C, YANG JZ, LV M, LIU R, HE DN, FAN CH, HUANG Q
  • 作者关键词:   graphene oxide, ultrasmall, stability, cytotoxicity, cellular uptake, nanocarrier
  • 出版物名称:   ACS APPLIED MATERIALS INTERFACES
  • ISSN:   1944-8244
  • 通讯作者地址:   NERCN
  • 被引频次:   98
  • DOI:   10.1021/am303005j
  • 出版年:   2013

▎ 摘  要

Graphene oxide (GO) is an increasingly important nanomaterial, which exhibits great promise in the area of bionanotechnology and nanobiomedicine. In this study, we synthesized uniform ultrasmall graphene oxide nanosheets with high yield by a convenient way of modified Hummers method. The uniform ultrasmall GO nanosheets, which exhibit fluorescence property and outstanding stability in a wide range of pH values, were less than 50 nm. Furthermore, because of the advantages of its lateral size, the uniform ultrasmall GO nanosheets showed excellent biocompatibility of lower cytotoxicity and higher cellular uptake amount compared to the random large GO nanosheets. Therefore, the as-prepared uniform ultrasmall GO nanosheets could be explored as the ideal nanocarriers for drug delivery and intracellular fluorescent nanoprobe.