• 文献标题:   Reduced graphene oxide aerogel networks with soft interfacial template for applications in bone tissue regeneration
  • 文献类型:   Article
  • 作  者:   ASHA S, ANANTH AN, JOSE SP, RAJAN MAJ
  • 作者关键词:   aerogel, graphene oxide, hydroxyapatite, chitosan, soft interfacial template
  • 出版物名称:   APPLIED NANOSCIENCE
  • ISSN:   2190-5509 EI 2190-5517
  • 通讯作者地址:   Arul Anandar Coll
  • 被引频次:   2
  • DOI:   10.1007/s13204-018-0803-z
  • 出版年:   2018

▎ 摘  要

Reduced Graphene Oxide aerogels (A-RGO), functionalized with chitosan, were found to induce and/or accelerate the mineralization of hydroxyapatite. The functionalized chitosan acts as a soft interfacial template on the surface of A-RGO assisting the growth of hydroxyapatite particles. The mineralization on these soft aerogel networks was performed by soaking the aerogels in simulated body fluid, relative to time. Polymer-induced mineralization exhibited an ordered arrangement of hydroxyapatite particles on reduced graphene oxide aerogel networks with a higher crystalline index (IC) of 1.7, which mimics the natural bone formation indicating the importance of the polymeric interfacial template. These mineralized aerogels which mimic the structure and composition of natural bone exhibit relatively higher rate of cell proliferation, osteogenic differentiation and osteoid matrix formation proving it to be a potential scaffold for bone tissue regeneration.