▎ 摘　　要

NOVELTY - The integrated microneedle (1) has drug delivery microneedles and several diagnostic electrodes (2). The diagnostic electrode is arranged around the drug delivery microneedle. The microneedle for administration includes several microneedles for administration. The drug delivery microneedles are loaded with drugs. The diagnostic electrode comprises a printed circuit board (PCB). The PCB is provided with several electrode microneedles. The electrode microneedles are modified with aptasensors. Each diagnostic electrode diagnoses a physical and chemical factor in the wound exudate through the aptamer sensor on the diagnostic electrode. The electrode microneedles pass through the flexible circuit board and the electrochemical analyzer. The electrochemical analyzer (4) is connected with a display (5). USE - Integrated microneedle for diagnosis and treatment of skin wounds and regenerate damaged skin. ADVANTAGE - The integrated microneedle for diagnosis and treatment of wounds can obtain physical and chemical data of the wound in a timely manner while administering drugs to the wound, to facilitate real-time knowledge of the wound status and provide a more accurate treatment plan for wound treatment. The preparation method of the integrated microneedle for wound diagnosis and treatment can produce the microneedle for administration. The preparation method of the electrode microneedle is simple. The biosensor combines with the aptamer factor in the wound exudate by preparing the corresponding aptamer on the electrode microneedle body, so that the physical and chemical factors in the exudate can be obtained to achieve the detection effect. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a preparation method for integrated microneedles for diagnosis and treatment of wounds, which involves preparing the integrated microneedle for drug delivery by weighing the biodegradable polymer, adding the polymer into deionized water to fully dissolve, and obtaining a polymer soluble polymer solution. A part of the high molecular soluble polymer solution is added for adding drugs and fully stirring and dissolving to obtain a high molecular soluble polymer solution loaded with drugs. The drug-loaded polymer soluble polymer solution is injected into the mold and dried to obtain drug-loaded microneedles. A part of the high-molecular-soluble polymer solution is used as a high-molecular-soluble polymer solution without loading drugs when the drug-loaded microneedles are not solidified. The drug-free high molecular soluble polymer solution is injected into the mold until the mold is filled, so that the drug-free high molecular soluble polymer solution forms a microneedle base on the bottom of the drug-loaded microneedles. The diagnostic electrodes are manufactured using the magnetorheological technology to form liquid microneedles on the printed circuit board, keeping the liquid microneedles under an external magnetic field, placing the prebaked microneedles in an oven and curing to obtain electrode microneedles, sputtering gold-plated/titanium film at the end of the electrode microneedle body, sequentially electrodepositing polyaniline nanofibers and platinum nanoparticles on the gold-plated/titanium film, modifying the electrochemically exfoliated graphene-gold nanoparticle nanocomposite material, modifying the aptamer marker on the electrochemically exfoliated graphene-gold nanoparticle nanocomposite material to detect the aptamer marker in the wound and/or preparing on the electrochemically exfoliated graphene-gold nanoparticle nanocomposite material pH sensor. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic diagram of an integrated microneedle for diagnosis and treatment of skin wounds. 1Integrated microneedle 2Diagnosis electrode 4Electrochemical analyzer 5Display 11Substrate