• 专利标题:   Preparing collagen-graphene oxide cross-linked scaffold material with uniform porous structure useful for tissue engineering bone repair field, comprises immersing collagen-graphene oxide gel in liquid nitrogen, freezing and drying.
  • 专利号:   CN112724450-A
  • 发明人:   LIU Y
  • 专利权人:   UNIV CHANGZHOU
  • 国际专利分类:   A61L027/44, A61L027/56, A61L027/58, C08J003/24, C08J009/28, C08K003/04, C08K005/29, C08L089/00
  • 专利详细信息:   CN112724450-A 30 Apr 2021 C08J-009/28 202148 Pages: 5 Chinese
  • 申请详细信息:   CN112724450-A CN10002802 04 Jan 2021
  • 优先权号:   CN10002802

▎ 摘  要

NOVELTY - Preparing collagen-graphene oxide cross-linked scaffold material with uniform porous structure comprises (i) preparing a certain concentration of collagen solution, carbodiimide and N-hydroxysuccinyl solution; (ii) preparing graphene oxide solution of a certain concentration, and slowly adding graphene oxide solution into the collagen solution in certain proportion to obtain collagen-graphene oxide blending solution; (iii) adding corresponding proportion of carbodiimide and N-hydroxysuccinyl solution into the collagen-graphene oxide blending solution, crosslinking agent and catalyst, stirring fully to generate the cross-linking reaction to be cast into the mold to gel; (iv) completely immersing collagen-graphene oxide gel in liquid nitrogen, performing quick freezing treatment, and transferring the sample to a -80 degrees C refrigerator for storage; and (v) vacuum freeze-drying frozen sample. USE - The collagen-graphene oxide cross-linked scaffold material is useful for tissue engineering bone repair field. ADVANTAGE - The material has good physical and chemical properties and biocompatibility. The method is simple, and has controllable molding, and simple device. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for: a collagen-graphene oxide cross-linked scaffold material prepared by the above mentioned method.