▎ 摘　　要

NOVELTY - A transdermal drug delivery microneedle system comprises water-soluble polyacrylic acid, drug and graphene nanosheets. The transdermal drug delivery microneedle system has a microneedle height of 300-800 mu m, a microneedle tip width of 10-20 mu m and a microneedle bottom width of 200-400 mu m. USE - Transdermal drug delivery microneedle system is useful for treating skin surface tumor (claimed). ADVANTAGE - The transdermal drug delivery microneedle system has excellent photothermal effect and improved drug delivery efficiency and drug loading capacity, and adjusts the photothermal heating effect by changing the content of the embedded graphene nanosheets. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for the method for preparing the transdermal drug delivery microneedle system, which involves adding polyacrylic acid to deionized water and gently oscillating until polyacrylic acid is completely dissolved, adding graphene nanosheets and medicines to the dissolved solution, stirring the mixture for 1-2 hours so that the graphene nanosheets and the medicines are fully dispersed in the aqueous polyacrylic acid solution, adjusting the content of deionized water so that the viscosity of the slurry is 20-800 Pa.second, adding the slurry to polydimethylsiloxane (PDMS) microneedle mold, centrifuging at 3000-5000 rpm for 15 minutes in a centrifuge, taking out, adding one-half microneedle volume of slurry to PDMS microneedle mold, continuously centrifuging at the same speed for 15 minutes, adding pure aqueous polyacrylic acid solution to the PDMS microneedle mold, completely filling the mold space and removing excess slurry as the base of the microneedle, and drying the sample in an oven at 37 degrees C for 24 hours, and demolding to obtain the transdermal drug delivery microneedle system.