• 专利标题:   New contrast agent, prepared by chemically bonding the bridge molecule to graphene oxide surface, and reacting complex molecule with the bridging molecule attached to the surface of graphene oxide to form surface complex molecule.
  • 专利号:   WO2015039555-A1, CN104436221-A, CN104436221-B
  • 发明人:   ZHANG M, ZHANG Z
  • 专利权人:   SUZHOU INST NANOTECH NANOBIONICS, CHINESE ACAD SCI SUZHOU NANOTECH NANO
  • 国际专利分类:   A61K049/06, A61K049/08, C01B031/04, A61K047/04, A61K047/34, A61K047/36, A61K047/42, A61K049/00, A61K049/10, A61K049/12, A61K049/14
  • 专利详细信息:   WO2015039555-A1 26 Mar 2015 A61K-049/06 201524 Pages: 28 Chinese
  • 申请详细信息:   WO2015039555-A1 WOCN085611 29 Aug 2014
  • 优先权号:   CN10435341

▎ 摘  要

NOVELTY - Contrast agent (I), is new. USE - The contrast agent intermediate is useful for preparing the contrast agent (claimed). ADVANTAGE - The contrast agent has high relaxation, good stability, and non-specificity. DETAILED DESCRIPTION - Contrast agent of formula (A-(B-R)n) (I), is new. A = graphene oxide or functional group-modified graphene oxide; R = gadolinium metal complex, formed by Ra and gadolinium metal complex molecules; B = bridging molecule, formed by bonding of chemical bonds with the graphene oxide surface, and bonding of chemical bonds with the gadolinium metal complexes; - = a bond; and n = greater than 1. INDEPENDENT CLAIMS are also included for: (1) preparing the contrast agent; (2) a contrast agent composition, comprising the contrast agent and a diluent; (3) angiography, comprising administering the contrast agent composition to a subject or a sample be imaged, and carrying out angiography; (4) medicine composition, comprising contrast agent as a drug carrier, an active ingredient loaded on the contrast agent, and a carrier; and (5) a contrast agent intermediate (II).